天然物化学研究室 : 大栗研究室 Oguri Lab.

 

大栗研究室では、生命進化の歴史が刻み込まれた天然物の構造・生合成・自然界での役割を学んで機能性分子群を設計し、自在に迅速合成する手法を開発しています。有機合成化学を駆使して、生合成経路を合理的に改変・拡張するアプローチを提案しています。骨格レベルの構造多様性を系統的に創出し,多官能性分子群を構築するプロセスを開発します。抗感染症・制ガン活性を発現するリード化合物群を創製するとともに,共有結合性リガンドを活用したケミカルバイオロジー研究に取り組んでいます。また、天然物の構造に潜在する分子認識能力を顕在化させ、超分子化学と融合した研究を展開しています。一連の研究と教育を通じて、新しい価値を創造し、化学研究・産業を先導していく次世代リーダーの育成を目指していきます。

In the Oguri laboratory, we are developing concise and flexible synthetic approaches to generate functional molecules based on the structure, biosynthesis, and biological roles of natural products as the evolutionary consequences of life. With integration of the biosynthetic logics and modern strategies of organic synthesis, biomimetic modular assembly lines were devised to gain divergent access to skeletally diverse molecules. The densely functionalized natural products and their variants have been utilized as covalent ligands to investigate chemical genetic and medicinal research relevant to infectious diseases and tumors. We are also exploring the interface of natural products and supramolecular chemistry by harnessing the largely untapped potential of natural products bearing specific molecular recognition capabilities. Our research and educational activities are aimed at nurturing the next generation leaders who create new values and explore the frontier of chemical research and industries.

研究室見学、随時歓迎いたします。
事前に hirokioguri[at]g.ecc.u-tokyo.ac.jp へご連絡ください。

Visiting our laboratory is always welcome.
Please contact Prof. Oguri (hirokioguri[at]g.ecc.u-tokyo.ac.jp) in advance.

大学院生(修士・博士)募集中!
We’re seeking graduate students to join our team!

入試に関しては下記をご覧ください。
For more information on admissions, please check the following links.

受験希望者は事前に大栗 (hirokioguri[at]g.ecc.u-tokyo.ac.jp) へご連絡ください。 対面/Web面談(Zoomなど)を実施する予定です。
If you are interested in taking the exam, please contact Hiroki Oguri (hirokioguri[at]g.ecc.u-tokyo.ac.jp) in advance. Onsite or Web interviews (Zoom, etc.) will be conducted.


What's New

2022.11.10 Naoto Haraguchi-san (M2) has presented our research and received Outstanding Presentation award on “The 121st Symposium on Organic Synthesis”. Congratulations!... ...Read more
2022.10.03 Wang Xinrui-san (D1) and Chloe Lipinski-san (M1) have joined!... ...Read more
2022.09.22 Gavin Tay-san has acquired his bachelor’s degree from The University of Tokyo. Congratulations!... ...Read more
2022.09.09 Tasuku Honda-san has presented our research on “The 64th Symposium on the chemistry of natural products @ Shizuoka prefecture.”... ...Read more
2022.09.09 The interview article of Professor Oguri has been appeared on “RIGAKU-RU”.... ...Read more
2022.09.08 Assistant Professor Ryo Tanifuji has received a memorial plate of "63rd Encouragement Award of Symposium on the Chemistry of Natural Products".... ...Read more
2022.08.26 New benches has been introduced!... ...Read more
2022.08.06 We held a reunion party in Sapporo to celebrate Professor Oikawa's retirement from Hokkaido University.... ...Read more