天然物化学研究室 : 大栗研究室 Oguri Lab.

 

大栗研究室では、生命進化の歴史が刻み込まれた天然物の構造・生合成・自然界での役割を学んで機能性分子群を設計し、自在に迅速合成する手法を開発しています。有機合成化学を駆使して、生合成経路を合理的に改変・拡張するアプローチを提案しています。骨格レベルの構造多様性を系統的に創出し,多官能性分子群を構築するプロセスを開発します。抗感染症・制ガン活性を発現するリード化合物群を創製するとともに,共有結合性リガンドを活用したケミカルバイオロジー研究に取り組んでいます。また、天然物の構造に潜在する分子認識能力を顕在化させ、超分子化学と融合した研究を展開しています。一連の研究と教育を通じて、新しい価値を創造し、化学研究・産業を先導していく次世代リーダーの育成を目指していきます。

In the Oguri laboratory, we are developing concise and flexible synthetic approaches to generate functional molecules based on the structure, biosynthesis, and biological roles of natural products as the evolutionary consequences of life. With integration of the biosynthetic logics and modern strategies of organic synthesis, biomimetic modular assembly lines were devised to gain divergent access to skeletally diverse molecules. The densely functionalized natural products and their variants have been utilized as covalent ligands to investigate chemical genetic and medicinal research relevant to infectious diseases and tumors. We are also exploring the interface of natural products and supramolecular chemistry by harnessing the largely untapped potential of natural products bearing specific molecular recognition capabilities. Our research and educational activities are aimed at nurturing the next generation leaders who create new values and explore the frontier of chemical research and industries.

研究室見学、随時歓迎いたします。
事前に hirokioguri[at]g.ecc.u-tokyo.ac.jp へご連絡ください。

Visiting our laboratory is always welcome.
Please contact Prof. Oguri (hirokioguri[at]g.ecc.u-tokyo.ac.jp) in advance.

大学院生(修士・博士)募集中!
We’re seeking graduate students to join our team!

入試に関しては下記をご覧ください。
For more information on admissions, please check the following links.

受験希望者は事前に大栗 (hirokioguri[at]g.ecc.u-tokyo.ac.jp) へご連絡ください。 対面/Web面談(Zoomなど)を実施する予定です。
If you are interested in taking the exam, please contact Hiroki Oguri (hirokioguri[at]g.ecc.u-tokyo.ac.jp) in advance. Onsite or Web interviews (Zoom, etc.) will be conducted.


What's New

2024.02.05 Front cover! The picture of Honda-san's achivments published in Angew. Chem. Int. Ed. has been selected as the Front cover, congratulations!... ...Read more
2024.01.22 Honda-san's paper for Natural Product-Based Figure-Eight Macrocycles has been published on Angewandte Chemie! This accomplishment was made possible through collaborative research with a lot of group, led by Prof. Sato, Prof. Muraoka, Prof. Yuasa, and... ...Read more
2023.09.26 Lab trip to Echigoyuzawa (Niigata Pref.)!... ...Read more
2023.09.15 Wayama-san (D1) made an oral presentation about his dihydropyridine chemistry on 第65回天然有機化合物討論会!... ...Read more
2023.09.10 Ishiga-san (D1) made a poster presentation about his 6-aza-artemisinin chemistry and biology on 2023年度若手支援技術講習会 @ Nagoya!... ...Read more
2023.09.04 Assistant Prof. Tanifuji has made an invited presentation at the faculty of Pharmaceutical Sciences, Tohoku Univ.... ...Read more
2023.09.01 A new MERIT student! Ryo Minamikawa-san (M1) has been selected as a MERIT-WINGS student, congratulations!... ...Read more
2023.08.28 Haraguchi-san (D1) made an oral presentation about his chemo-enzymatic approach on 生合成若手シンポジウム!... ...Read more