天然物化学研究室 : 大栗研究室 Oguri Lab.

 

大栗研究室では、生命進化の歴史が刻み込まれた天然物の構造・生合成・自然界での役割を学んで機能性分子群を設計し、自在に迅速合成する手法を開発しています。有機合成化学を駆使して、生合成経路を合理的に改変・拡張するアプローチを提案しています。骨格レベルの構造多様性を系統的に創出し,多官能性分子群を構築するプロセスを開発します。抗感染症・制ガン活性を発現するリード化合物群を創製するとともに,共有結合性リガンドを活用したケミカルバイオロジー研究に取り組んでいます。また、天然物の構造に潜在する分子認識能力を顕在化させ、超分子化学と融合した研究を展開しています。一連の研究と教育を通じて、新しい価値を創造し、化学研究・産業を先導していく次世代リーダーの育成を目指していきます。

In the Oguri laboratory, we are developing concise and flexible synthetic approaches to generate functional molecules based on the structure, biosynthesis, and biological roles of natural products as the evolutionary consequences of life. With integration of the biosynthetic logics and modern strategies of organic synthesis, biomimetic modular assembly lines were devised to gain divergent access to skeletally diverse molecules. The densely functionalized natural products and their variants have been utilized as covalent ligands to investigate chemical genetic and medicinal research relevant to infectious diseases and tumors. We are also exploring the interface of natural products and supramolecular chemistry by harnessing the largely untapped potential of natural products bearing specific molecular recognition capabilities. Our research and educational activities are aimed at nurturing the next generation leaders who create new values and explore the frontier of chemical research and industries.

研究室見学、随時歓迎いたします。
事前に hirokioguri[at]g.ecc.u-tokyo.ac.jp へご連絡ください。

Visiting our laboratory is always welcome.
Please contact Prof. Oguri (hirokioguri[at]g.ecc.u-tokyo.ac.jp) in advance.

 

大学院生(修士・博士)募集中!
We’re seeking graduate students to join our team!

入試に関しては下記をご覧ください。
For more information on admissions, please check the following links.

受験希望者は事前に大栗 (hirokioguri[at]g.ecc.u-tokyo.ac.jp) へご連絡ください。 対面/Web面談(Zoomなど)を実施する予定です。
If you are interested in taking the exam, please contact Hiroki Oguri (hirokioguri[at]g.ecc.u-tokyo.ac.jp) in advance. Onsite or Web interviews (Zoom, etc.) will be conducted.


What's New

2024.09.25 Inside back cover! The picture of Tay-san and Nishimura-san's achievements published in Chem. Sci. has been selected as the Inside back cover, congratulations!... ...Read more
2024.09.25 Tay-san and Nishimura-san's paper on the photo [4+2] and [2+2] reactions of dehydrosecodine-type substrates has been published as an Edge Article in Chemical Science! A press release was issued, and it was also featured on the Nikkei newspaper's web ... ...Read more
2024.09.25 Lab trip to Nasushiobara (Tochigi Pref.)!... ...Read more
2024.09.20 Two members have obtained their master’s degrees from the University of Tokyo. Congratulations to Tay-san and Lipinski-san!... ...Read more
2024.09.19 Assistant Prof. Tanifuji participated in the 40th Organic Synthesis Chemistry Seminar, gave an poster presentation.... ...Read more
2024.09.05 Ishiga-san gave an oral presentation on the anti-hepatic fibrosis activity of the 6-aza-artemisinins at the 66th Symposium on the Chemistry of Natural Products (第66回天然有機化合物討論会)!... ...Read more
2024.08.25 Haraguchi-san, Hata-san, Hasegawa-san, and Tanifuji-san have presented our progress on “at the Young Researchers' Meeting on Forecasting Biosynthesis”.... ...Read more
2024.08.23 Prof. Oguri delivered an invited lecture at the "2nd Symposium for the Distinguished Lectureship Awards on The International Cutting-Edge Organic Chemistry in Asia," held in Bangkok, Thailand.... ...Read more